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pentobarbital will lower the level or result of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a lower in fentanyl plasma concentrations, lack of efficacy or, probably, improvement of a withdrawal syndrome in a affected indi

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